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TB-9

CAT: 0804-HY-164956Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164956Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TB-9, a Tasiamide B derivative, is a potent cathepsin D, cathepsin E, and BACE1 inhibitor with IC50s of 0.0783 nM, 0.724 nM, and 54.2 nM, respectively[1].
CAS Number
1415033-91-8
UNSPSC
12352005
Target
Beta-secretase; Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tb-9.html
Smiles
O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(OC)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C55H76N8O12
Molecular Weight
1041.24
References & Citations
[1]Zhi Li, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25 (4) :e3154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; Cathepsin D; Cathepsin E

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