TB-21007

• Description :

  TB-21007 is a selective and brain penetrant α5 subunit-containing GABAA receptor inverse agonist with Kis of 1.6 nM, 20 nM, 16 nM, and 20 nM for α5, α1, α2 and α3 subtypes, respectively. TB-21007 enhances cognition in rats[1].

• UNSPSC :

  12352005

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tb-21007.html

• Purity :

  99.7

• Solubility :

  DMSO : 40 mg/mL (ultrasonic; warming)

• Smiles :

  O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21

• Molecular Formula :

  C15H17NO2S3

• Molecular Weight :

  339.50

• References & Citations :

  [1]Chambers MS, et al. Identification of a novel, selective GABA (A) alpha5 receptor inverse agonist which enhances cognition. J Med Chem. 2003 May 22;46 (11) :2227-40.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [207306-50-1]