TB-11

• Description :

  TB-11 is a Cathepsin D inhibitor, with IC50s of 0.126 nM (Cathepsin D), 1.92 nM (Cathepsin E), 48.8 nM (BACE1), respectively. TB-11 can be used for tumor research[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase; Cathepsin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tb-11.html

• Smiles :

  CC(C)(C)OC(N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(OC)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C52H78N8O12

• Molecular Weight :

  1007.22

• References & Citations :

  [1]Li Z, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25 (4) :e3154.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  BACE1; Cathepsin D; Cathepsin E

• CAS Number :

  [1415033-93-0]