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α-Synuclein aggregate binder 1

CAT: 0804-HY-160116-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160116-01Size:5 mg
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Description
α-Synuclein aggregate binder 1 (Compound C05-05) is a specific binder for α-synuclein aggregates and can inhibit α-synuclein aggregation. α-Synuclein aggregate binder 1 can be used as a fluorescent probe (excitation wavelength 900 nm, detection wavelength 500-550 nm) for optical imaging, and can also inhibit α-synuclein fibril formation by blocking the aggregation process. α-Synuclein aggregate binder 1 can be used for positron emission tomography (PET) imaging after being labeled with 18F. α-Synuclein aggregate binder 1 can be used for visual diagnosis of brain lesions and mechanism research of neurodegenerative diseases such as Parkinson's disease and Lewy body dementia[1][2].
CAS Number
1565797-17-2
UNSPSC
12352005
Target
Fluorescent Dye; Radionuclide-Drug Conjugates (RDCs) ; α-synuclein
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-synuclein-aggregate-binder-1.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNC1=NC=C(C=C1)C#C/C=C/C(SC2=C3)=NC2=CC=C3OCC(O)CF
Molecular Formula
C20H18FN3O2S
Molecular Weight
383.44
References & Citations
[1]Higuchi M, et al., Novel α-synuclein aggregate binding agents for disease diagnosis using optical imaging. WO2020174963.|[2]Preparation of novel but-1-en-3-yne compound, α-synuclein aggregate binder, and use thereof. World Intellectual Property Organization, WO2023163033 A1. 2023-08-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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