KKL-40

• Description :

  KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells[1].

• Product Name Alternative :

  Hydroxytolbutamide

• UNSPSC :

  12352005

• Target :

  Antibiotic; Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/kkl-40.html

• Purity :

  95.70

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)C3=CC=CC(C(F)(F)F)=C3

• Molecular Formula :

  C16H9F4N3O2

• Molecular Weight :

  351.26

• References & Citations :

  [1]A Small Molecule Inhibitor of Trans -Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides to Impair Survival of Staphylococcus aureus.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [865285-47-8]