22 (R) -Hydroxycholesterol

• Description:

  22 (R) -Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22 (R) -Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1].

• Product Name Alternative:

  Narthesterol

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  LXR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/22-r-hydroxycholesterol.html

• Purity:

  99.86

• Solubility:

  Ethanol : ≥ 100 mg/mL

• Smiles:

  O[C@@H](CC[C@@]12C)CC1=CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@]4([H])[C@H](C)[C@@H](CCC(C)C)O)[H])C)[H])[H]

• Molecular Formula:

  C27H46O2

• Molecular Weight:

  402.65

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275 (36) :28240-5.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [17954-98-2]