2-Thiouridine

CAT: 0804-HY-117813-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-117813-01Size:50 mg
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Description
2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ([HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) [1][2][3][4].
CAS Number
[20235-78-3]
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
CHIKV; Dengue Virus; DNA/RNA Synthesis; Flavivirus; Nucleoside Antimetabolite/Analog; SARS-CoV
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/2-thiouridine.html
Purity
99.76
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
S=C(N1)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=CC1=O
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Heuberger BD, et al. Replacing uridine with 2-thiouridine enhances the rate and fidelity of nonenzymatic RNA primer extension. J Am Chem Soc. 2015 Feb 25;137 (7) :2769-75. |[2]Kumar RK, et al. Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability. Nucleic Acids Res. 1997 Mar 15;25 (6) :1272-80.|[3]Larsen AT, et al. Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization. Nucleic Acids Res. 2015 Sep 18;43 (16) :7675-87.|[4]Uemura K, et al. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses. Proc Natl Acad Sci U S A. 2023 Oct 17;120 (42) :e2304139120.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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