4′-Thiouridine

• Description:

  4′-Thiouridine (1- (4-Thio-beta-D-ribofuranosyl) uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing[1][2][3].

• Product Name Alternative:

  1- (4-Thio-beta-D-ribofuranosyl) uracil

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Nucleoside Antimetabolite/Analog

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/4-thiouridine.html

• Purity:

  98.68

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O

• Molecular Formula:

  C9H12N2O5S

• Molecular Weight:

  260.27

• Precautions:

  H302

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Benckendorff CMM, et al., Preparation of a 4'-Thiouridine Building-Block for Solid-Phase Oligonucleotide Synthesis. Curr Protoc. 2023 Sep;3 (9) :e878.|[3]Garibaldi A, et al., Isolation of Newly Transcribed RNA Using the Metabolic Label 4-Thiouridine. Methods Mol Biol. 2017;1648:169-176.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [6741-73-7]