2’-O-Methyl-4-thiouridine

• UNSPSC Description:

  2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/2-o-methyl-4-thiouridine.html

• Solubility:

  H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C(NC(C=C2)=S)=O)O1

• Molecular Weight:

  274.29

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  34218-80-9