Pentamidine (isethionate)

Pentamidine (isethionate)

• CAS Number: 140-64-7
• UNSPSC Description: Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
• Target Antigen: Antibiotic; Bacterial; Fungal; Parasite; Phosphatase
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/Pentamidine-isethionate.html
• Purity: 99.92
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
• Smiles: N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.OCCS(=O)(O)=O.OCCS(=O)(O)=O
• Molecular Weight: 592.68
• References & Citations: [1]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.|[2]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.|[3]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.Cell Rep Methods. 2023 Oct 23;3(10):100599.|Biochem Biophys Res Commun. 2019 Sep 17;517(2):221-226.|BMC Womens Health. 2022 Nov 24;22(1):470.|Drug Des Dev Ther. 2021 Jul 1;15:2857-2868.|Immunity. 2023 Feb 14;56(2):272-288.e7.|Int J Mol Sci. 2023 Sep 5, 24(18), 13812.|Microbiol Spectr. 2023 May 1;e0313822.|Molecules. 2020 Apr 23;25(8):1980.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Launched