Pentamidine (isethionate)

CAT: 0804-HY-B0537B-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0537B-01Size:50 mg
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Description
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
CAS Number
[140-64-7]
Product Name Alternative
MP-601205 (isethionate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Fungal; Parasite; Phosphatase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Pentamidine-isethionate.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.OCCS(=O)(O)=O.OCCS(=O)(O)=O
Molecular Formula
C23H36N4O10S2
Molecular Weight
592.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7 (5) :625-34.|[2]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1 (14) :1255-64.|[3]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2 (10) : p. 1387-400.|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Leishmania; Trypanosoma
Citation 01
Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Biochem Biophys Res Commun. 2019 Sep 17;517 (2) :221-226.|BMC Womens Health. 2022 Nov 24;22 (1) :470.|Drug Des Devel Ther. 2021 Jul 1;15:2857-2868.|Immunity. 2023 Feb 14;56 (2) :272-288.e7.|Int J Mol Sci. 2023 Sep 7;24 (18) :13812.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0313822.|Molecules. 2020 Apr 23;25 (8) :1980.

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