Pentamidine

• UNSPSC Description:

  Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

• Target Antigen:

  Antibiotic; Bacterial; Fungal; Parasite; Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/pentamidine.html

• Purity:

  97.19

• Solubility:

  DMSO : 6.25 mg/mL (ultrasonic)

• Smiles:

  N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N

• Molecular Weight:

  340.42

• References & Citations:

  [1]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.|[2]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.|[3]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.Biochem Biophys Res Commun. 2019 Sep 17;517(2):221-226.|BMC Womens Health. 2022 Nov 24;22(1):470.|Drug Des Dev Ther. 2021 Jul 1;15:2857-2868.|Immunity. 2023 Feb 14;56(2):272-288.e7.|Int J Mol Sci. 2023 Sep 5, 24(18), 13812.|Microbiol Spectr. 2023 May 1;e0313822.|Molecules. 2020 Apr 23;25(8):1980.|Cell Rep Methods. 2023 Oct 23;3(10):100599.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  Launched

• CAS Number:

  100-33-4