Pentamidine

CAT: 0804-HY-B0537-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0537-01Size:5 mg
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Description
Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
CAS Number
[100-33-4]
Product Name Alternative
MP-601205
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Fungal; Parasite; Phosphatase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/pentamidine.html
Purity
97.19
Solubility
DMSO : 3.3 mg/mL (ultrasonic; warming; adjust pH to 6 with 1 M HCl; heat to 60°C)
Smiles
N=C(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N
Molecular Formula
C19H24N4O2
Molecular Weight
340.42
Precautions
H302, H315, H319, H335
References & Citations
[2]Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2 (10) : p. 1387-400.|[3]Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7 (5) :625-34.|[4]David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.|[1]Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1 (14) :1255-64.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Leishmania; Trypanosoma
Citation 01
Biochem Biophys Res Commun. 2019 Sep 17;517 (2) :221-226.|BMC Womens Health. 2022 Nov 24;22 (1) :470.|Drug Des Devel Ther. 2021 Jul 1;15:2857-2868.|Immunity. 2023 Feb 14;56 (2) :272-288.e7.|Int J Mol Sci. 2023 Sep 7;24 (18) :13812.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0313822.|Molecules. 2020 Apr 23;25 (8) :1980.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.

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