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MAP3K2 rabbit pAb

CAT: 0855-ES20233-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20233-02Size:100 µL
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Background
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
UniProt
Q9Y2U5
Swiss Prot
Q9Y2U5
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human MAP3K2 AA range: 220-300
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.
Other Product Names
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2)
Gene ID (Human)
10746

UniProtKB · Q9Y2U5

Mitogen-activated protein kinase kinase kinase 2

M3K2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y2U5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP3K2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
B9EG87, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

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