KYN-101

• UNSPSC Description:

  KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity[1].

• Target Antigen:

  Aryl Hydrocarbon Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kyn-101.html

• Smiles:

  CC1=C2N=C(C3=CC(F)=CN=C3)C=C(NCCC4=CNC5=C4C=CC=C5)N2N=C1

• Molecular Weight:

  386.42

• References & Citations:

  [1]Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2247950-73-6