ABT-288

• Description:

  ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research.[1].

• UNSPSC:

  12352005

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/abt-288.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1C[C@]2([H])N(C3=CC=C(C4=CC=C(N5C(C=CC=N5)=O)C=C4)C=C3)CC[C@]2([H])C1

• Molecular Formula:

  C23H24N4O

• Molecular Weight:

  372.46

• References & Citations:

  [1]Esbenshade TA, et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2012 Oct;343 (1) :233-45.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  H3 Receptor

• CAS Number:

  [948845-91-8]