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EGFR-IN-69

CAT: 0804-HY-150610-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150610-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research[1].
CAS Number
2433837-65-9
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-69.html
Purity
99.58
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=S(N1C=C(C2=NC(NC3=CC(Cl)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)=NC=C2Cl)C6=C1C=CC=C6)(CC)=O
Molecular Formula
C31H37Cl2N7O3S
Molecular Weight
658.64
References & Citations
[1]Chen H, et al. Conformational Constrained 4- (1-Sulfonyl-3-indol) yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65 (9) :6840-6858.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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