PQ-69

• Description :

  PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM) . PQ-69 can be used for the research of renal dysfunction[1].

• CAS Number :

  [910045-32-8]

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pq-69.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1N(C2=CC=CC(F)=C2)NC3=C1C(NCCCC)=NC4=CC=CC=C34

• Molecular Formula :

  C20H19FN4O

• Molecular Weight :

  350.39

• References & Citations :

  [1]Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10 (4) :619-29.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported