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NLRP3-IN-69

CAT: 0804-HY-170836Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170836Size:1 Each
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Description
NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κB p65 and the formation of NLRP3 inflammasome. NLRP3-IN-69 inhibits LPS -induced overexpression of IL-1β, iNOS and COX-2, inhibits NO generation (IC50=5.66 μM), thereby exhibiting anti-inflammatory activity[1].
CAS Number
3027608-60-9
UNSPSC
12352005
Target
COX; Interleukin Related; NF-κB; NO Synthase; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
COC1=C(OC)C(OC)=CC(/C=C/C(OC2=CC(C=CC([C@@H](C(O)=O)C)=C3)=C3C=C2)=O)=C1
Molecular Formula
C25H24O7
Molecular Weight
436.45
References & Citations
[1]Yu J, et al., Novel Cinnamic Acid Derivatives Containing Naproxen as NLRP3 Inhibitors: Synthesis and Evaluation of Their Biological Activity. Chem Biodivers. 2024 Dec 29:e202402700.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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