(E)-10-Hydroxynortriptyline

(E)-10-Hydroxynortriptyline

• CAS Number: 47132-16-1
• UNSPSC Description: (E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A)[1]. E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
• Target Antigen: Drug Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/e-10-hydroxynortriptyline.html
• Purity: 99.36
• Solubility: H2O : 3.57 mg/mL (ultrasonic;warming;heat to 60°C)|Methanol : ≥ 25 mg/mL
• Smiles: OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC
• Molecular Weight: 279.38
• References & Citations: [1]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.|[2]Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.|[3]Bertilsson L, Nordin C, Otani K, et al. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clin Pharmacol Ther. 1986;40(3):261-267. |[4]Dumont E, von Bahr C, Perry TL Jr, Bertilsson L. Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes. Pharmacol Toxicol. 1987;61(5):335-341.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported