(E) -10-Hydroxynortriptyline

CAT: 0804-HY-U00050-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-U00050-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417) . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A) [1]. E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
CAS Number
[47132-16-1]
Product Name Alternative
E-10-OH-NT
UNSPSC
12352005
Hazard Statement
H302
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-10-hydroxynortriptyline.html
Purity
99.65
Solubility
H2O : 3.57 mg/mL (ultrasonic; warming; heat to 60°C) |Methanol : ≥ 25 mg/mL
Smiles
OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC
Molecular Formula
C19H21NO
Molecular Weight
279.38
Precautions
H302
References & Citations
[1]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22 (4) :371-8.|[2]Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.|[3]Bertilsson L, Nordin C, Otani K, et al. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clin Pharmacol Ther. 1986;40 (3) :261-267. |[4]Dumont E, von Bahr C, Perry TL Jr, Bertilsson L. Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes. Pharmacol Toxicol. 1987;61 (5) :335-341.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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