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(Z) -10-Hydroxynortriptyline-d3

CAT: 0804-HY-100646AS-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-100646AS-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(Z) -10-Hydroxynortriptyline-d3 is the deuterium labeled (Z) -10-Hydroxynortriptyline. (Z) -10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1][2].
UNSPSC
12352005
Target
Drug Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.0
Solubility
10 mM in DMSO|DMF : ≥ 30mg/mL|DMSO : ≥ 10mg/mL|Ethanol : ≥ 5mg/mL
Smiles
OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C\CCNC([2H])([2H])[2H]
Molecular Formula
C19H18D3NO
Molecular Weight
282.40
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22 (4) :371-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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