(E)-KN-93 (phosphate)

• UNSPSC Description:

  (E)-KN-93 phosphate is an inhibitor for Ca2+/calmodulin-dependent protein kinase II (CaMK II) with IC50 of 9 μM and 3 μM, for CaMKIIδ monomer and CaMKIIδ dodecamer. (E)-KN-93 phosphate binds competitively with Ca2+/CaM, and disrupts their interaction with CaMK II, and thus inhibits the CaMK II activation[1].

• Target Antigen:

  CaMK

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-kn-93-phosphate.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=P(O)(O)O.O=S(N(C1=C(C=CC=C1)CN(C)C/C=C/C2=CC=C(C=C2)Cl)CCO)(C3=CC=C(C=C3)OC)=O

• Molecular Weight:

  599.03

• References & Citations:

  [1]Wong MH, et al., The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM. J Mol Biol. 2019 Mar 29;431(7):1440-1459.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  RT, stored under nitrogen

• Clinical Information:

  No Development Reported

• CAS Number:

  1188890-41-6