(E) -KN-93 (phosphate)

• Description :

  (E) -KN-93 phosphate is an inhibitor for Ca2+/calmodulin-dependent protein kinase II (CaMK II) with IC50 of 9 μM and 3 μM, for CaMKIIδ monomer and CaMKIIδ dodecamer. (E) -KN-93 phosphate binds competitively with Ca2+/CaM, and disrupts their interaction with CaMK II, and thus inhibits the CaMK II activation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H314

• Target :

  CaMK

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/e-kn-93-phosphate.html

• Purity :

  99.85

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=P(O)(O)O.O=S(N(C1=C(C=CC=C1)CN(C)C/C=C/C2=CC=C(C=C2)Cl)CCO)(C3=CC=C(C=C3)OC)=O

• Molecular Formula :

  C26H32ClN2O8PS

• Molecular Weight :

  599.03

• Precautions :

  H314

• References & Citations :

  [1]Wong MH, et al., The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM. J Mol Biol. 2019 Mar 29;431 (7) :1440-1459.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  RT, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CaMK II

• CAS Number :

  [1188890-41-6]