KN-93

• Description:

  KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; CaMK

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Neuronal Signaling

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/KN-93.html

• Purity:

  99.42

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=S (C1=CC=C (OC) C=C1) (N (C2=CC=CC=C2CN (C/C=C/C3=CC=C (Cl) C=C3) C) CCO) =O

• Molecular Formula:

  C26H29ClN2O4S

• Molecular Weight:

  501.04

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase) . Cell Growth Differ. 1995 Sep;6 (9) :1063-70.|[2]Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195 (2) :608-15.|[3]Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287 (3) :996-1006.|[4]Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39 (3) :1196-208.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CaMK II

• Citation 01:

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• CAS Number:

  139298-40-1