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Peptide5 (TFA)

CAT: 0804-HY-P2275B-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P2275B-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Peptide5 TFA, a connexin 43 mimetic peptide, reduces animals swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 TFA also inhibits NLRP3 inflammasome, and is an anti-inflammatory agent[1][2][3].
UNSPSC
12352209
Target
Connexin; Gap Junction Protein; NOD-like Receptor (NLR)
Type
Peptides
Related Pathways
Cytoskeleton; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/peptide5-tfa.html
Purity
98.87
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CS)NC([C@H](CC(O)=O)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O
Molecular Formula
C62H99F3N16O22S
Molecular Weight
1509.60
References & Citations
[1]Simon J O'Carroll, et al. Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. Cell Commun Adhes. 2008 May;15 (1) :27-42.|[2]Yilin Mao, et al. Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp Brain Res. 2017 Oct;235 (10) :3033-3048.|[3]Tonkin RS, et al. Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp Neurol. 2018 Feb;300:1-12.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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