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BIT-225

CAT: 0804-HY-106282-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-106282-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIT-225 is an inhibitor for Vpu protein through block of Vpu ion channel, and thus inhibits the release of HIV-1, especially in monocyte-derived macrophages (EC50 is 2.25 μM), without significant cytotoxicity (TC50 is 284 μM) [1].
CAS Number
[917909-71-8]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bit-225.html
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=CC(C3=CN(C)N=C3)=C2C=C1)NC(N)=N
Molecular Formula
C16H15N5O
Molecular Weight
293.32
References & Citations
[1]Khoury G, et al., Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob Agents Chemother. 2010 Feb;54 (2) :835-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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