SP-2-225

• Description :

  SP-2-225 is a selective HDAC6 inhibitor. SP-2-225 enhance the production of cancer-associated antigens and macrophage antigen cross-presentation to T cells. SP-2-225 reduces the tumor volume in a syngeneic SM1 melanoma model[1].

• UNSPSC :

  12352005

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sp-2-225.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C(COC2=CC=C(CNCCCCCC(NO)=O)C=C2C)C=CC=C1C3=CC=CC=C3

• Molecular Formula :

  C28H34N2O3

• Molecular Weight :

  446.58

• References & Citations :

  [1]Scott Grindrod, et al. Abstract PO023: Immune-mediated tumor growth inhibition by selective HDAC6 inhibitor SP-2-225. Cancer Immunol Res (2021) 9 (2_Supplement) : PO023.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2364448-93-9]