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NBQX (disodium)

CAT: 0804-HY-15068A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15068A-01Size:5 mg
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Description
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].
CAS Number
479347-86-9
Product Name Alternative
FG9202 (disodium)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nbqx-disodium.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C([N-]1)C([N-]C2=C1C3=C(C([N+]([O-])=O)=C2)C(S(N)(=O)=O)=CC=C3)=O.[Na+].[Na+]
Molecular Formula
C12H6N4Na2O6S
Molecular Weight
380.24
Precautions
H315, H319, H335
References & Citations
[1]Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19 (8) :1174-84.|[2]Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11 (11) :e0166672.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Chemical Information

NBQX disodium salt
CAS Number479347-86-9
PubChem CID6098006
IUPAC Namedisodium;6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
Molecular FormulaC12H6N4Na2O6S
Molecular Weight380.25
Topological Polar Surface Area186
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count1
Heavy Atom Count25
Formal Charge0
Complexity575
SMILES
C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])N=C(C(=N3)[O-])[O-].[Na+].[Na+]
InChI
InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2
InChIKey
SVJKYIUJRJEABK-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of NBQX disodium salt
CAS: 479347-86-9
CID: 6098006
Formula: C12H6N4Na2O6S
MW: 380.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.25
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count1
Exact Mass379.98034366
Monoisotopic Mass379.98034366
Topological Polar Surface Area186 Ų
Heavy Atom Count25
Formal Charge0
Complexity575
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
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BN164674NBQX disodium salt - Bio-X TM
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