NBQX

• Description:

  NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity[1].

• Product Name Alternative:

  FG9202

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  IGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/NBQX.html

• Purity:

  99.82

• Solubility:

  1 M NaOH : 25 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : ≥ 75 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (N1) C (NC2=C1C3=C (C ([N+] ([O-]) =O) =C2) C (S (N) (=O) =O) =CC=C3) =O

• Molecular Formula:

  C12H8N4O6S

• Molecular Weight:

  336.28

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19 (8) :1174-84.|[2]Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11 (11) :e0166672.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  AMPA Receptor

• CAS Number:

  118876-58-7