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RR-11055

CAT: 0804-HY-W1009348Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W1009348Size:1 Each
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Description
RR-11055 (Compound 8) is a ligand for E3 ligase, that exhibits an affinity with cereblon with Ki of 0.38 μM. RR-11055 can be used for synthesis of PROTAC Degrader ERD-1233.
CAS Number
3026009-09-3
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rr-11055.html
Smiles
O=C1C2=CC=C(N3[C@@](CNCC3)([H])CO4)C4=C2CN1[C@@H]5C(NC(CC5)=O)=O
Molecular Formula
C18H20N4O4
Molecular Weight
356.38
References & Citations
[1]Acharyya RK, et al., Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer. J Med Chem. 2024 Nov 14;67 (21) :19010-19037.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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