Tempol

CAT: 0804-HY-100561-01Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-100561-01Size:200 mg

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Description

Tempol is a general superoxide dismutase (SOD) -mimetic agent that efficiently neutralizes reactive oxygen species (ROS) .

CAS Number

2226-96-2

Product Name Alternative

4-Hydroxy-TEMPO

UNSPSC

12352005

Hazard Statement

H302, H318, H402

Target

Autophagy; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tempol.html

Purity

99.78

Solubility

H2O : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[O]N1C(C)(C)CC(O)CC1(C)C

Molecular Formula

C9H18NO2

Molecular Weight

172.24

Precautions

H302, H318, H402

References & Citations

[1]Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12 (10) :e1005947.|[2]Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug;58 (2) :658-73.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Reference compound1

Clinical Information

Phase 3

Chemical Information

Tempol

4-hydroxy-TEMPO is a member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. It has a role as a catalyst, an antineoplastic agent, a radical scavenger, a hepatoprotective agent, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a nephroprotective agent. It is a member of aminoxyls and a hydroxypiperidine. It is functionally related to a TEMPO.

CAS Number	2226-96-2
PubChem CID	137994
Molecular Formula	C9H18NO2
Molecular Weight	172.24
XLogP	0.9
Topological Polar Surface Area	24.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	12
Formal Charge	0
Complexity	159

SMILES

CC1(CC(CC(N1[O])(C)C)O)C

InChI

InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3

InChIKey

UZFMOKQJFYMBGY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2226-96-2

CID: 137994

Formula: C9H18NO2

MW: 172.24

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	172.24
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	172.133753817
Monoisotopic Mass	172.133753817
Topological Polar Surface Area	24.5 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	159
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-W001187-01	Tempo
HY-112879-01	Mito-TEMPO
HY-151847-01	N3-TEMPO
HY-W001187S	Tempo-d18
HY-W001187R-01	Tempo (Standard)
HY-W002004-01	4-Amino-TEMPO
HY-129242-01	Tempone
HY-140512	Acid-PEG5-TEMPO
HY-W002004S1-01	4-Amino-TEMPO-d17
HY-129242S1	Tempone-d16

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MBS3603560-01	Tempol

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