Tempone

• Description:

  Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure[1].

• Product Name Alternative:

  4-Oxo-Tempo

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H317, H372, H410

• Target:

  SOD

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/tempone.html

• Purity:

  99.10

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  [O]N1C(C)(C)CC(CC1(C)C)=O

• Molecular Formula:

  C9H16NO2?

• Molecular Weight:

  170.23

• Precautions:

  H302, H317, H372, H410

• References & Citations:

  [1]Patel N S A, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney[J]. Free Radical Biology and Medicine, 2002, 33 (11) : 1575-1589.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2896-70-0]