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Tempo-d18

CAT: 0804-HY-W001187SSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W001187SSize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tempo-d18 is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].
CAS Number
205679-68-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.90
Solubility
10 mM in DMSO
Smiles
[O]N1C(C([2H])([2H])[2H])(C([2H])([2H])C([2H])([2H])C([2H])([2H])C1(C([2H])([2H])[2H])C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C9D18NO
Molecular Weight
174.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91 (2) :761-773.|[3]Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1163 (1) :214-225.|[4]Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22.|[5]Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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