Tempo

• UNSPSC Description:

  Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells[1][2][3][4].

• Target Antigen:

  DNA/RNA Synthesis; Mitochondrial Metabolism; Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tempo.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  [O]N1C(C)(C)CCCC1(C)C

• Molecular Weight:

  156.25

• References & Citations:

  [1]Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.|[2]Kaur G, et al. Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. Mol Carcinog. 2010 Mar;49(3):290-301.|[3]Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2564-83-2