Tempo (Standard)

• Description:

  Tempo (Standard) is the analytical standard of Tempo. This product is intended for research and analytical applications. Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H314-H412

• Target:

  DNA/RNA Synthesis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS) ; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tempo-standard.html

• Smiles:

  [O]N1C(C)(C)CCCC1(C)C

• Molecular Formula:

  C9H18NO

• Molecular Weight:

  156.25

• Precautions:

  P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P405-P501

• References & Citations:

  [1]Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.|[2]Kaur G, et al. Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. Mol Carcinog. 2010 Mar;49 (3) :290-301.|[3]Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163 (1) :214-225.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [2564-83-2]