TA-316 (GMP)

CAT: 0804-HY-112486G-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-112486G-01Size:10 mg

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Description

TA-316 (GMP) is TA-316 produced by using GMP guidelines. GMP grade small molecules can be used as auxiliary agents in cell therapy. TA-316 is a c-MPL agonist and a thrombopoietin (TPO) receptor agonist[1].

CAS Number

1429321-13-0

Product Name Alternative

Megakaryocytes/platelets inducing agent (GMP)

UNSPSC

12352005

Target

Cyclin G-associated Kinase (GAK)

Type

GMP Small Molecules

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ta-316-gmp.html

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\C

Molecular Formula

C28H25BrN4O5S2

Molecular Weight

641.56

References & Citations

[1]Aihara A, et al. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells[J]. Blood advances, 2017, 1 (7) : 468-476.

Shipping Conditions

Blue Ice

Storage Conditions

Keep sealed and protect from light, store at 2-8°C

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Chemical Information

(2E)-2-[1-[5-(4-Bromophenyl)-4-hydroxy-3-thienyl]ethylidene]hydrazide-5-[[[[4-[[(2-hydroxyethyl)amino]carbonyl]phenyl]methyl]amino]carbonyl]-2-thiophenecarboxylic Acid

CAS Number	1429321-13-0
PubChem CID	71533707
IUPAC Name	2-N-[(E)-1-[5-(4-bromophenyl)-4-hydroxythiophen-3-yl]ethylideneamino]-5-N-[[4-(2-hydroxyethylcarbamoyl)phenyl]methyl]thiophene-2,5-dicarboxamide
Molecular Formula	C28H25BrN4O5S2
Molecular Weight	641.6
XLogP	4.4
Topological Polar Surface Area	197
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Heavy Atom Count	40
Formal Charge	0
Complexity	911

SMILES

C/C(=N\NC(=O)C1=CC=C(S1)C(=O)NCC2=CC=C(C=C2)C(=O)NCCO)/C3=CSC(=C3O)C4=CC=C(C=C4)Br

InChI

InChI=1S/C28H25BrN4O5S2/c1-16(21-15-39-25(24(21)35)18-6-8-20(29)9-7-18)32-33-28(38)23-11-10-22(40-23)27(37)31-14-17-2-4-19(5-3-17)26(36)30-12-13-34/h2-11,15,34-35H,12-14H2,1H3,(H,30,36)(H,31,37)(H,33,38)/b32-16+

InChIKey

SOHAFPZIBGBALX-KPGMTVGESA-N

Chemical Structure

2D Structure

CAS: 1429321-13-0

CID: 71533707

Formula: C28H25BrN4O5S2

MW: 641.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	641.6
XLogP3	4.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	640.04497
Monoisotopic Mass	640.04497
Topological Polar Surface Area	197 Å²
Heavy Atom Count	40
Formal Charge	0
Complexity	911
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-112486-01	TA-316
HY-176913	TA
HY-119134	PX-316
HY-173427S	ZK-316
HY-171190	ELQ-316
HY-100253	TA-7552
HY-105060	TA 077
HY-123226	TA-606
HY-125347	TA-993
HY-19030	TA-1801

Alternative Products

Catalog	Name
T13769-01	TA-316
A13220-10	TA-316 10mg
A13220-5	TA-316 5mg
A13220-25	TA-316 25mg
A13220-1	TA-316 1mg
A13220-100	TA-316 100mg
A13220-50	TA-316 50mg
T69589-01	PX-316
GTR19211313-01	FK-316
GTR19258044-01	ZK-316

TA-316 (GMP)

Chemical Information

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