TA-316

• UNSPSC Description:

  TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2].

• Target Antigen:

  Cyclin G-associated Kinase (GAK)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Megakaryocytes-platelets_inducing_agent.html

• Purity:

  98.04

• Solubility:

  DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=CC=C(C(NCC2=CC=C(C(NCCO)=O)C=C2)=O)S1)N/N=C(C3=CSC(C4=CC=C(Br)C=C4)=C3O)\C

• Molecular Weight:

  641.56

• References & Citations:

  [1]METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS.WO2013051625A1.|[2]Aihara A, et al. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Adv. 2017;1(7):468-476. Published 2017 Feb 28.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1429321-13-0