YT-8-8

• UNSPSC Description:

  YT-8-8 is a ligand of p62-ZZ domain. YT-8-8 can activate p62-dependent selective macroautophagy. YT-8-8 can be used for AUTOTAC design[1].

• Target Antigen:

  AUTOTACs; p62

• Type:

  Reference compound

• Related Pathways:

  Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/yt-8-8.html

• Smiles:

  OCCNCCNCC1=CC(OCC2=CC=C(F)C=C2)=CC=C1

• Molecular Weight:

  318.39

• References & Citations:

  [1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  892572-23-5