PROTAC α-synuclein degrader 5

• CAS Number:

  2781922-42-5

• UNSPSC Description:

  PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research[1].

• Target Antigen:

  PROTACs; α-synuclein

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;PROTAC

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/protac-α-synuclein-degrader-5.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CNC4=CC(C5=CC(C6=CC7=C(C=C6)OCO7)=NN5)=CC=C4

• Molecular Weight:

  767.78

• References & Citations:

  [1]Yichen Tong, et.al. Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates. Journal of Medicinal Chemistry 2023 66 (12), 7926-7942

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported