MY-1076

CAT: 0804-HY-155360-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-155360-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC50 s of 0.019, 0.017, 0.020 and 0.044 μM, respectively[1].

CAS Number

3008262-76-5

UNSPSC

12352005

Target

Apoptosis; YAP

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/my-1076.html

Purity

99.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)N(C2=CC(OC)=C(OC)C(OC)=C2)CC3=CC(O)=C(OC)C=C3

Molecular Formula

C29H33NO9

Molecular Weight

539.57

References & Citations

[1]Xiang-Jing Fu, et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities, European Journal of Medicinal Chemistry, Volume 262, 2023, 115883.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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