MY-1076

• UNSPSC Description:

  MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC50 s of 0.019, 0.017, 0.020 and 0.044 μM, respectively[1].

• Target Antigen:

  Apoptosis; YAP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/my-1076.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)N(C2=CC(OC)=C(OC)C(OC)=C2)CC3=CC(O)=C(OC)C=C3

• Molecular Weight:

  539.57

• References & Citations:

  [1]Xiang-Jing Fu, et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities, European Journal of Medicinal Chemistry, Volume 262, 2023, 115883.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3008262-76-5