MY-1576

CAT: 0013-GTR19249418-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19249418-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MY-1576 is a potent FAK inhibitor (IC50 = 8 nM) that activates the Hippo pathway to suppress YAP/TAZ activity. It demonstrates robust anti-tumor efficacy in KYSE30 xenograft models and effectively reduces FAK autophosphorylation and YAP/TAZ levels in vivo, supporting its use in cancer research.

CAS Number

3097026-24-6

Field of Research

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Smiles

CNC (C1=CC=CC=C1NC2=NC (NC3=CC=C (NC (N4CCN (CC) CC4) =O) C=C3) =NC=C2Cl) =O

Molecular Formula

C25H29ClN8O2

Molecular Weight

509.01

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

N-[4-[[5-chloro-4-[2-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]phenyl]-4-ethylpiperazine-1-carboxamide

CAS Number	3097026-24-6
PubChem CID	177838641
IUPAC Name	N-[4-[[5-chloro-4-[2-(methylcarbamoyl)anilino]pyrimidin-2-yl]amino]phenyl]-4-ethylpiperazine-1-carboxamide
Molecular Formula	C25H29ClN8O2
Molecular Weight	509.0
XLogP	3.8
Topological Polar Surface Area	115
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	36
Formal Charge	0
Complexity	714

SMILES

CCN1CCN(CC1)C(=O)NC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4C(=O)NC)Cl

InChI

InChI=1S/C25H29ClN8O2/c1-3-33-12-14-34(15-13-33)25(36)30-18-10-8-17(9-11-18)29-24-28-16-20(26)22(32-24)31-21-7-5-4-6-19(21)23(35)27-2/h4-11,16H,3,12-15H2,1-2H3,(H,27,35)(H,30,36)(H2,28,29,31,32)

InChIKey

LBKYSWSHOQCXAH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 3097026-24-6

CID: 177838641

Formula: C25H29ClN8O2

MW: 509.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	509.0
XLogP3	3.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	508.2101999
Monoisotopic Mass	508.2101999
Topological Polar Surface Area	115 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	714
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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