MY-1B

CAT: 0804-HY-158301-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-158301-01Size:5 mg

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Description

MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM) . MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes[1][2][3].

CAS Number

[2929308-79-0]

UNSPSC

12352005

Target

DNA Methyltransferase; RNA MTase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/my-1b.html

Purity

99.94

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@H]1[C@@H](C2=CC=C(C=C2)Br)CN1C(C=C)=O)NC3=CC=CC4=C3N=CC=C4

Molecular Formula

C22H18BrN3O2

Molecular Weight

436.30

References & Citations

[1]Tao Y, et al. Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl. 2023 Dec 18;62 (51) :e202311924.|[2]Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144 (40) :18688-18699. |[3]Ng BW, et al. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics. Mol Cell. 2023 May 18;83 (10) :1544-1546.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T85335-01	MY-1B
A24365-5	MY-1B 5mg
A24365-50	MY-1B 50mg
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A24365-100	MY-1B 100mg
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