MY-1B

• Description:

  MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC50: 1.3 μM) . MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes[1][2][3].

• UNSPSC:

  12352005

• Target:

  DNA Methyltransferase; RNA MTase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/my-1b.html

• Purity:

  99.94

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C ([C@H]1[C@@H] (C2=CC=C (C=C2) Br) CN1C (C=C) =O) NC3=CC=CC4=C3N=CC=C4

• Molecular Formula:

  C22H18BrN3O2

• Molecular Weight:

  436.30

• References & Citations:

  [1]Tao Y, et al. Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2. Angew Chem Int Ed Engl. 2023 Dec 18;62 (51) :e202311924.|[2]Tao Y, et al. Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. J Am Chem Soc. 2022 Oct 12;144 (40) :18688-18699. |[3]Ng BW, et al. Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics. Mol Cell. 2023 May 18;83 (10) :1544-1546.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2929308-79-0