MY-1576

CAT: 0804-HY-170936Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-170936Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

MY-1576 is a FAK inhibitor with an IC50 of 8 nM. MY-1576 can activate the Hippo pathway, thereby blocking the regulation of YAP/TAZ. MY-1576 also effectively inhibits tumor growth in the KYSE30 xenograft mouse model, demonstrating good safety, and effectively downregulates the autophosphorylation of FAK and the levels of YAP/TAZ in vivo[1].

UNSPSC

12352005

Target

FAK; Hippo (MST) ; YAP

Related Pathways

Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

ClC(C(NC1=CC=CC=C1C(NC)=O)=N2)=CN=C2NC(C=C3)=CC=C3NC(N4CCN(CC4)CC)=O

Molecular Formula

C25H29ClN8O2

Molecular Weight

509.00

References & Citations

[1]Wang X, et al. Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma. Eur J Med Chem. 2025 Apr 5;287:117328.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

YAP/TAZ

Related Products

Catalog	Name
HY-155360-01	MY-1076
HY-149414-01	MY-673
HY-162089-01	MY-1442
HY-100933-01	MY-5445
HY-169147	MY-11B
HY-150761-01	MY-875
HY-149249-01	MY-943
HY-158301-01	MY-1B
HY-P991305	AGEN-1571
HY-161175-01	IMP-1575

Alternative Products

Catalog	Name
GTR19249418-01	MY-1576
ABC-TC0716	MY
B6301-5	MY-5445
BA2899-5	MY-1076
JH918885	MY-3
MBS5819824	MY-943
GTR19237090-01	MY-1B
584765	MY 5445
T68238-01	MY 336-a
T78798-01	MY-673

MY-1576

Related Products

Alternative Products

Popular Products