MY-1576

• Description:

  MY-1576 is a FAK inhibitor with an IC50 of 8 nM. MY-1576 can activate the Hippo pathway, thereby blocking the regulation of YAP/TAZ. MY-1576 also effectively inhibits tumor growth in the KYSE30 xenograft mouse model, demonstrating good safety, and effectively downregulates the autophosphorylation of FAK and the levels of YAP/TAZ in vivo[1].

• UNSPSC:

  12352005

• Target:

  FAK; Hippo (MST) ; YAP

• Related Pathways:

  Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  ClC (C (NC1=CC=CC=C1C (NC) =O) =N2) =CN=C2NC (C=C3) =CC=C3NC (N4CCN (CC4) CC) =O

• Molecular Formula:

  C25H29ClN8O2

• Molecular Weight:

  509.00

• References & Citations:

  [1]Wang X, et al. Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma. Eur J Med Chem. 2025 Apr 5;287:117328.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  YAP/TAZ