MY-673

• Target:

  Apoptosis|||Others|||ERK|||Microtubule Associated|||TGF-beta/Smad

• Related Pathways:

  Cytoskeletal Signaling|||Stem Cells|||Apoptosis|||Others|||MAPK

• Bioactivity:

  MY-673, a colchicine binding site inhibitor (CBSI), impedes tubulin polymerization and disrupts the ERK signaling pathway, consequently modulating SMAD4 protein expression in the TGF-?/SMAD pathway. This compound effectively reduces cell proliferation and migration while inducing apoptosis in both in vivo and in vitro settings [1].

• Smiles:

  O=C1CN (C=2C (=CC (OC) =CC2) N1) C=3C=4C (OC (=O) C3) =CC=CC4

• Molecular Formula:

  C18H14N2O4

• Molecular Weight:

  322.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2944459-96-3