YM-341619

CAT: 0804-HY-134771-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134771-01Size:5 mg
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Description
YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation[1]. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma[2].
CAS Number
[643082-52-4]
Product Name Alternative
AS1617612
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ym-341619.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1NCC4=C(F)C=CC(F)=C4F)N
Molecular Formula
C22H21F3N6O2
Molecular Weight
458.44
References & Citations
[1]Shinya Nagashima, et al. Identification of 4-benzylamino-2-[ (4-morpholin-4-ylphenyl) amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg Med Chem. 2008 Jul 1;16 (13) :6509-21. 9.15|[2]Keiko Ohga, et al.YM-341619 suppresses the differentiation of spleen T cells into Th2 cells in vitro, eosinophilia, and airway hyperresponsiveness in rat allergic models. Eur J Pharmacol. 2008 Aug 20;590 (1-3) :409-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT6

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