YM-341619

• UNSPSC Description:

  YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation[1]. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma[2].

• Target Antigen:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ym-341619.html

• Smiles:

  O=C(C1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1NCC4=C(F)C=CC(F)=C4F)N

• Molecular Weight:

  458.44

• References & Citations:

  [1]Shinya Nagashima, et al. Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg Med Chem. 2008 Jul 1;16(13):6509-21. 9.15|[2]Keiko Ohga,et al.YM-341619 suppresses the differentiation of spleen T cells into Th2 cells in vitro, eosinophilia, and airway hyperresponsiveness in rat allergic models. Eur J Pharmacol. 2008 Aug 20;590(1-3):409-16.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  643082-52-4