Thymine-d4

• Description:

  Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.

• UNSPSC:

  12352005

• Hazard Statement:

  H319

• Target:

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Field of Research:

  Cancer; Metabolic Disease

• Purity:

  98

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(C([2H])([2H])[2H])=C([2H])NC(N1)=O

• Molecular Formula:

  C5H2D4N2O2

• Molecular Weight:

  130.14

• Precautions:

  H319

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  RT, sealed storage, away from moisture and light

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [200496-79-3]