Thymine-d4

• Description :

  Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer; Metabolic Disease

• Purity :

  98

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C(C([2H])([2H])[2H])=C([2H])NC(N1)=O

• Molecular Formula :

  C5H2D4N2O2

• Molecular Weight :

  130.14

• Precautions :

  H319

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  RT, sealed storage, away from moisture and light

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [200496-79-3]