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Thymine-13C5,15N2

CAT: 0804-HY-W010450S5-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-W010450S5-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thymine-13C5,15N2 (5-Methyluacil-13C5,15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[1].
CAS Number
2483830-13-1
Product Name Alternative
5-Methyluacil-13C5,15N2
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thymine-13c5-15n2.html
Smiles
O=[13C]1[13C]([13CH3])=[13CH][15NH][13C]([15NH]1)=O
Molecular Formula
13C5H6 15N2O2
Molecular Weight
133.06
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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