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K2C75 rabbit pAb

CAT: 0855-ES15362-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES15362-01Size:50 µL
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Background
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS) . [provided by RefSeq, Oct 2008]
Description
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008],
UniProt
O95678
Swiss Prot
O95678
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human K2C75 AA range: 272-322
Target
K2C75
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Intermediate filament, keratin filament, extracellular exosome
Gene ID (Human)
9119

UniProtKB · O95678

Keratin, type II cytoskeletal 75

K2C75_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95678
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
KRT75
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DQU4, Q9NSA9
Protein keywords

Domain

Coiled coil

Disease

Disease variant

Cellular component

Intermediate filamentKeratin

Technical term

Proteomics identificationReference proteome

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