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FCE 28654

CAT: 0804-HY-U00369Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-U00369Size:1 Each
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Description
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
CAS Number
169474-77-5
UNSPSC
12352005
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Urea,_N-[2,6-bis_1-methylethyl_phenyl]-N_acute_-[[_4R,5R_-4,5-dimethyl-2-[4-_phosphonooxy_phenyl]-1,3-dioxolan-2-yl]methyl]-.html
Solubility
10 mM in DMSO
Smiles
CC(C)C(C=CC=C1C(C)C)=C1NC(NCC2(C3=CC=C(OP(O)(O)=O)C=C3)O[C@H](C)[C@@H](C)O2)=O
Molecular Formula
C25H35N2O7P
Molecular Weight
506.53
References & Citations
[1]A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5 (15) :1581-1586.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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