CFTR corrector 15

• Description:

  CFTR corrector 15 (Compound 4172) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that repairs the F508del-CFTR folding defect when used with VX-809 (HY-13262) . CFTR corrector 15 can be used in research of cystic fibrosis disease[1].

• UNSPSC:

  12352005

• Target:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/cftr-corrector-15.html

• Purity:

  99.67

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC1=CC(NC(N2N=C(C=C2NC(C3(CCCC3)C4=CC=C(C=C4)Cl)=O)C5=CC=CS5)=N1)=O

• Molecular Formula:

  C24H22ClN5O2S

• Molecular Weight:

  479.98

• References & Citations:

  [1]Vaccarin C, et al., Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) . J Med Chem. 2024 Aug 22;67 (16) :13891-13908.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1170387-92-4]