CFTR corrector 15

CAT: 0804-HY-164000-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-164000-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CFTR corrector 15 (Compound 4172) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that repairs the F508del-CFTR folding defect when used with VX-809 (HY-13262) . CFTR corrector 15 can be used in research of cystic fibrosis disease[1].
CAS Number
[1170387-92-4]
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cftr-corrector-15.html
Purity
99.67
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC(NC(N2N=C(C=C2NC(C3(CCCC3)C4=CC=C(C=C4)Cl)=O)C5=CC=CS5)=N1)=O
Molecular Formula
C24H22ClN5O2S
Molecular Weight
479.98
References & Citations
[1]Vaccarin C, et al., Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) . J Med Chem. 2024 Aug 22;67 (16) :13891-13908.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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