CFTR corrector 14

CFTR corrector 14

• UNSPSC Description: CFTR corrector 14 (Compound SVQ26) is a class 3 corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that promotes the CFTR activity (EC50 of 3.08 μM with presence of C1 class corrector VX-809). CFTR corrector 14 regulates the mutant-caused misfolding and impaired function of the CFTR protein. CFTR corrector 14 can be used in research about cystic fibrosis[1].
• Target Antigen: CFTR
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/cftr-corrector-14.html
• Smiles: BrC1=CC(CN2C(C(OCC)=O)=C(Br)C3=C2C4=NC(NS(C5=CC=CC=C5)(=O)=O)=NC=C4CC3)=CC=C1
• Molecular Weight: 646.35
• References & Citations: [1]Barreca M, et al., Identification of 6,9-dihydro-5H-pyrrolo[3,2-h]quinazolines as a new class of F508del-CFTR correctors for the treatment of cystic fibrosis. Eur J Med Chem. 2024 Jul 20;276:116691.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported