MLT-985

• Description :

  MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies[1][2].

• UNSPSC :

  12352005

• Target :

  MALT1

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mlt-985.html

• Purity :

  99.49

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CO[C@H](C1=C(NC(NC2=CN=C(N3N=CC=N3)C(Cl)=C2)=O)C=NC4=CC(Cl)=NN14)C

• Molecular Formula :

  C17H15Cl2N9O2

• Molecular Weight :

  448.27

• References & Citations :

  [1]Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63 (23) :14594-14608.|[2]Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1832576-25-6]